Deep within an uncharted jungle in South America, a team of biotech researchers disappears without a trace while investigating rumors of accelerated evolution in native species. When a private extraction unit is sent to recover them, they uncover a horrifying truth: a new breed of genetically-altered anaconda—larger, faster, and more intelligent—now rules the forest.

Unlike any predator seen before, this serpent doesn’t just hunt to survive—it hunts to dominate. As the jungle closes in and the body count rises, the survivors must fight not just nature, but the monstrous creation of science gone wrong.

In this next chapter of the Anaconda franchise, fear coils tighter than ever.